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Glyburide (Glibenclamide)
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Glyburide

Glyburide belongs to a class of medicines called biguanides. It works by lowering glucose production in the liver, delaying the absorption of sugar from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Benclamet, Betanase, Betrol, Daocon, Daonil, Diabetnil, Diabnil, Diolin, Dutrol, Euglucon, Eumet, Giclamide, Glibact, Glibenclamide, Glibet, Glifil, Glime, Glinil, Glucomin, Gluconil, Glucored, Glucosil, Glunil, Glutowin, Glybenclamide, Glybid, Glybovin, Glybovine, Melitus, Pionorm, Sugatrol, Sugnil, Sugnl, Triglucored, Triglycomet

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Claritin, Eriacta, Pepcid, Cenforce, Nexium, Buspar, Myambutol, Epivir, Baktar, Sedate, Zosec, Pdnol, Catapres, Panlee, Prosip, Xputum, Lisiken, Meloprax,

Also known as: Glibenclamide

Description

Glyburide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glyburide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Glyburide and metformin is not for treating type 1 diabetes.

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.

Overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Glyburide dosage information

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Glyburide if you are allergic to it, or if:

you are being treated with bosentan (Tracleer); you have type 1 diabetes; or you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

hemolytic anemia (a lack of red blood cells); an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a nerve disorder affecting bodily functions; liver or kidney disease; or an allergy to sulfa drugs.

Before taking Glyburide, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Glyburide may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using Glyburide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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Proteases were present also in the cell envelope, corresponding to the inner membrane fraction of gram-negative bacteria, and intracellularly and were removable by detergent and French press treatment. All patients admitted to five patient care units (one medical intensive care unit, two surgical intensive care units, and two medical general care units) in one academic tertiary care hospital were studied between February and July 1993. However, the frequency of re-treatment has not yet been determined and the impact of prior or combined treatment with laser photocoagulation on the primary outcome is unclear. The evidence for the low/oscillatory shear theory is less robust than commonly assumed. A screening radial immunodiffusion system was used on 2.607 blood donors samples. What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice?.

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Distinctive glycerophospholipid profiles of human seminoma and adjacent normal tissues by desorption electrospray ionization imaging mass spectrometry. According to fundus fluorescein angiography images characteristics, this paper proposes a feature based image mosaic vessel edge method. Effect of oral sucrose on pain during DPT immunization in older infants. The method for generating a single BN captures relationships that would be overlooked by other approaches in the literature. The heat-tolerance mechanisms of (hyper)thermophilic proteins provide a unique opportunity to investigate the unsolved protein folding problem. Balance training in the aquatic environment is often used in rehabilitation practice to improve static and dynamic balance. The differential diagnoses for the clinical and pathological characteristics of this patient are discussed. Monitoring of expiratory flow rates and lung volumes during a high altitude expedition. Although many years of research have led to much knowledge about foot-and mouth disease and its causative agent, there are still numerous aspects of the virus and the disease that are not yet fully understood.

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Eighty-six patients underwent total mesorectal excision (TME) alone, 28 patients received preoperative RT (25 Gy in 5 fractions) followed by TME in 1 week, and 37 patients received preoperative CCRT (50.4 Gy in 28 fractions) followed by TME in 4-6 weeks. In this study, we examined the effect of acute capsaicin injection on nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d, a histochemical index of nitric oxide, NO, synthase) and Fos expression in the rat pituitary gland. Case report and review of the literature show difficulties in diagnosis and prognosis of gastric leiomyosarcoma. Although female contraceptives are very effective at preventing unintended pregnancy, some women can not use them because of health conditions or side-effects, leaving some couples without effective contraceptive options. In addition to delineating the basic principles that govern what precautions must be considered when using flow cytometry for the analysis of platelet vesicles, we provide an overview for how to standardize, control, annotate, and report EV flow cytometry data reproducibly, while looking forward to a next generation of high sensitivity instruments for the analysis of EVs and other submicron biomaterials in the circulation.

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When diploid cells of Saccharomyces cerevisiae homozygous for the temperature-sensitive cell division cycle mutation cdc6-1 are grown at a semipermissive temperature they exhibit elevated genomic instability, as indicated by enhanced mitotic gene conversion, mitotic intergenic recombination, chromosomal loss, chromosomal gain, and chromosomal rearrangements. No difference in cancer detection rate has yet been observed between FFDM and SFM. Comparison of emergency department crowding scores: a discrete-event simulation approach. His illness was diagnosed as polyangiitis overlap syndrome, because of the unclassified systemic necrotizing vasculitis. Education and Research at the Department of Medical Informatics Maastricht.

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Ectopic expression of the homeodomain transcription factor HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making HOXB4 a highly interesting candidate for therapeutic stem cell expansion. We assessed the effects of genotype by calculating study specific and pooled odds ratios (ORs) in meta-analyses, and assessed small study bias. In this paper we present sound velocity measurements made with different microorganisms. New data on the taxonomy of Leishmania circulating in populations of Rhombomys opimus, their main host, and the results of field and laboratory studies allowed revision of certain concepts generally accepted in epidemiology and epizootology of ZCL in Central Asia. When compared to MRA as anchor, darusentan, CAA and RDN are not more effective in achieving a clinically significant reduction in ambulatory blood pressure in individuals with apparent treatment-resistant hypertension. There was low to moderate quality evidence suggesting no significant differences in morbidity, mortality, length of hospital stay, or quality of life between antecolic and retrocolic reconstruction routes for gastro- or duodenojejunostomy. Changes in OA alignment before and after surgery are associated with changes in the subaxial spine. Technique for blood conservation in ABIOMED BVS 5000 ventricular assist device exchange. There were a wide variety of housing options in the region, but housing availability was not evenly distributed.

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