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Duonex (Duloxetine)
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Duonex

Duonex is a type of antidepressant known as a serotonin–norepinephrine reuptake inhibitor used to treat depression and anxiety. Duonex may improve your mood, sleep, appetite, and energy level, and decrease nervousness.

Other names for this medication:
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Also known as: Duloxetine

Description

Duonex (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression.

Duonex is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Duonex is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).

Duonex is also used to treat fibromyalgia (a chronic pain disorder) in adults and children at least 13 years old.

Dosage

Usual Adult Dose for Depression:

Initial dose: 20 mg to 30 mg orally 2 times a day Maintenance dose: 60 mg per day, given either once a day OR 30 mg orally 2 times a day Maximum dose: 120 mg/day.

Usual Adult Dose for Fibromyalgia:

Initial dose: 30 mg orally once a day for at least 1 week Maintenance dose: 30 to 60 mg orally once a day.

Usual Adult Dose for Generalized Anxiety Disorder:

Initial dose: 60 mg orally once a day Maintenance dose: 60 to 120 mg orally once a day Maximum dose: 120 mg/day.

Usual Adult Dose for Pain:

Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day.

Usual Adult Dose for Neuropathic Pain:

Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day.

Usual Adult Dose for Chronic Pain:

Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day.

Usual Geriatric Dose for Generalized Anxiety Disorder:

Initial dose: 30 mg orally once a day for at least 2 weeks Maintenance dose: 60 mg orally once a day Maximum dose: 120 mg/day.

Usual Pediatric Dose for Generalized Anxiety Disorder:

7 to 17 years: -Initial dose: 30 mg orally once a day for at least 2 weeks -Maintenance dose: 30 to 60 mg orally once a day -Maximum dose: 120 mg/day.

Usual Pediatric Dose for Fibromyalgia:

13 years and older: -Initial dose: 30 mg orally once a day for at least 1 week -Maintenance dose: 30 to 60 mg orally once a day.

Detailed Duonex dosage information

Overdose

If you take an overdose of Duonex, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a room temperature between 4 and 30 degrees C (39 and 86 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Duonex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Duonex if you are allergic to Duloxetine, other SNRIs or to any of the medication's components. Do not take Duonex if you have taken recreational drugs such as ecstasy (MDMA), ketamine, LSD, poppers (amyl nitrate), narcotics or benzodiazepines. Do not take Duonex if you are taking other medications, including erythromycin, alpha-blockers, antifungal medications (ketoconazole and itraconazole), medications for HIV (ritonavir, saquinavir, nelfinavir and atazanavir), certain antibiotics (telithromycin), alprazolam (Xanax), anticoagulants (warfarin), antidepressants (Elavil, Asendin, Anafranil, Norpramin), MAOI antidepressants (Marplan, Nardil, Eldepryl, Emsam, Zelapar), SSRI antidepressants (fluvoxamine), herbal remedy St. John’s Wort, NSAIDs (Advil, Motrin, Aleve, Naprosyn), clopidogrel (Plavix), diazepam (Valium), digoxin (Lanoxin), diuretics ('water pills'), linezolid, flecainide (Tambocor), medications for diabetes, lithium (Eskalith, Lithobid), medications for anxiety and Parkinson's disease, methylene blue, medications for mental illness (Clozaril, Haldol), medications for migraine (Axert, Relpax, Frova, Amerge), medications for seizures (Tegretol, Dilantin), sedatives, sibutramine (Meridia), sleeping pills, tramadol (Ultram), tranquilizers, and vinblastine (Velban). Do not take Duonex if you experience seizures (convulsions or fits). Do not take Duonex if you suffer from or have history of cardiovascular disease, liver or kidney disorders, hypotension, leukemia, peptic ulcer disease, rhinitis, glaucoma, epilepsy. Do not take Duonex if you have a history of fainting, mania (feeling overexcited, irritable or not being able to think clearly) or severe depression. Do not take Duonex if you have recently undergone a surgery. Do not to consume alcohol, drive or operate machinery while using Duonex, as it can lower your blood pressure, causing dizziness, drowsiness. Duonex is not for use in patients under age 18 years.

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Protein intake was assessed using two interviewer-administered 24-hour recalls, and body composition was assessed using bioelectrical impedance analysis (BIA) of fat mass (kg) (FM), fat free mass (kg) (FFM), and impedance resistance (Ohms). Perfusing sodium nitroprusside (SNP), however, did not inhibit irET-1 secretion. Experimental autoimmune uveoretinitis (EAU) is a model for posterior uveitis in humans. Linear regression analysis was performed to identify trends in use. Metal Interactions with Microbial Biofilms in Acidic and Neutral pH Environments. Patients treated in community clinics, particularly those of minority status, may rely more heavily on primary care physicians (PCPs) for the diagnosis and management of depression. This study compares the biochemical responses in T cells activated with the CD28 ligands B7-1 and B7-2.

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Viral vector gene delivery provides a novel approach to test the hypothesis that increased expression of antioxidant enzymes, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. The outcome of congenital diaphragmatic hernia (CDH) remains poor despite recent advances in neonatal care. In that period the derepression of mutant DNA occurs and malignant growth of tumor starts. Bronchoalveolar lavage for the diagnosis of Pulmonary Langerhans cell histiocytosis. CREB phosphorylation and DNA binding were measured by Western immunodetection and electrophoretic mobility shift assays (EMSA), respectively. To investigate the association between mild to severe psoriasis and comorbidities, data were obtained from 133 patients. Relative left frontal activity in reappraisal and suppression of negative emotion: Evidence from frontal alpha asymmetry (FAA).

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Clozapine induction of ERK1/2 cell signalling via the EGF receptor in mouse prefrontal cortex and striatum is distinct from other antipsychotic drugs. Ancient schwannoma of the parotid gland: a case report and review of the literature. The task of solving the CPMCSCF equations is approached using a parallelization scheme that partitions the electronic hessian matrix over all processors as opposed to simple partitioning of the 3 N solution vectors among the processors. This is a prospective study with 216 patients undergoing Roux-en-Y gastric bypass. Under salt stress condition, compared to wild-type (WT) plants, transgenic Arabidopsis grew better, had higher seedling fresh (FW), dry weight (DW), seed yields, proline content and lower MDA content and relative electric conductivity level. Thereafter changes were implemented with Plan-Do-Study-Act (PDSA) cycles to analyse their outcomes. This work concerns the effects of concurrent ball milling (BM) and octenyl succinic anhydride (OSA) modification on the starch microstructure and physicochemical properties (swelling, emulsifying, and rheological). Here, we show that PSEUDO RESPONSE REGULATOR (PRR) proteins directly mediate this stabilization. It will likely become more important for US allergy/immunology practices to demonstrate immunotherapy comparative-effectiveness and report quality measures.

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Time costs of fertility care: the hidden hardship of building a family. An analytical study is presented for the magnetic-field-induced motion of a colloidal sphere with spontaneous electrochemical reactions on its surface situated at the center of a spherical cavity filled with an electrolyte solution at the quasi-steady state. Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes. Prostate-specific membrane antigen (PSMA)-targeting radioligand therapy (RLT) was introduced in 2011. A case 67-year old male was admitted with abdominal blunt injury from a traffic accident. A 4 X 3 X 3 cm pituitary tumor with hypothalamic extension was removed via a transsphenoidal approach. We demonstrated the functionality and usefulness of our program in performing MVD evaluation.

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Olfactory assessment of predation risk in the aquatic environment. Diet composition related to body fat in a multivariate study of 203 men. Discriminative stimulus effects of H(1)-anti-histamines in cocaine-trained pigeons. Other aspects of therapy, such as potential side effects and absolute and relative contraindications, are also discussed. A 73-year old man presented with 7 cm asymptomatic left internal iliac artery aneurysm 12 years after repair of an abdominal aortic aneurysm with a bifurcation graft.

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Salmeterol and paroxetine: more evidence for paradoxical medicine. Evidence of alterations in the expression of orphan receptors GPR26 and GPR39 due to the etiology of the metabolic syndrome. Ischemia represents the main factor leading to the decrease of gastric mucosa protective mechanisms. Superficial siderosis of central nervous system in patients with brachial plexus injury. The PFPFQ is a reliable and internally consistent instrument for determining prefracture physical function in community-dwelling people who fracture their hip. The sequential treatment showed a decrease in retinal thickness after 1 and 12 weeks. The absence of many physical symptoms of pregnancy, inexperience, general inattentiveness to bodily cues, intense psychological conflicts about the pregnancy, and external stresses can contribute to the denial in otherwise well-adjusted women. Elevated circulating levels of monocyte chemoattractant protein-1 in patients with restenosis after coronary angioplasty. This review highlights mysterious and useful roles of selenium in biological processes. Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis.

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