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Doran (Ondansetron)
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Doran

Doran is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Other names for this medication:
Acidom, Domar, Doran, Emitus, Lupisetron, Odanse, Omcet, Ondansetron, Ondar, Ondet, Onsett, Ontron, Onzil, Osetron, Pantorex, Rancet, Renol, Supracetron, Vomicare, Vomigo, Vomikind, Vomipra, Vomiven, Vomiz, Vomizen, Xondmet, Zondan

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Also known as: Ondansetron

Description

Generic Doran is used for preventing nausea and vomiting due to cancer chemotherapy or surgery. It may also be used for other conditions. Generic Doran is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (e.g., chemotherapy). Doran is also known as Ondansetron, Vomiof, Danzetron, Ondaz. Generic name of Generic Doran is Ondansetron. Brand name of Generic Doran is Doran.

Dosage

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Doran ODT. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Doran dosage information

Side effects

The most common side effects associated with Doran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use this medicine if you are allergic to ondansetron, or if you are also using apomorphine (Apokyn).

To make sure ondansetron is safe for you, tell your doctor if you have:

liver disease; heart disease, congestive heart failure, a heart rhythm disorder; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); a personal or family history of Long QT syndrome; or a condition for which you take a diuretic or "water pill."

Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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To investigate whether the inclusion of a rub and rinse step before contact lens disinfection has an impact on solution-induced corneal staining. These results suggest a fundamental difference in turnover mechanisms at minisatellites between mice and human. In two phantoms with vessels between 0.3 and 6 mm diameter the slowest measurable blood flow with the different techniques was determined. In 1575 Pieter Aertsen (1508?-1575) painted the biblical story of the healing of a lame man at Bethesda (John 5:1-9). Hypnale hypnale (hump-nosed pit viper) is a medically important venomous snake in Sri Lanka and Southwestern India. Murine and human endothelial cells were exposed to ethanol for up to 72 hours. Preparation of Chito-Oligomers by Hydrolysis of Chitosan in the Presence of Zeolite as Adsorbent. This is due to limitations in the optical system, data storage, and alignment and vignette issues. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Parsimony, likelihood, and Bayesian analyses of the separate gene regions and combined data reveal five major lineages and refute the conventional elevation of the flying squirrels (Pteromyinae) to subfamily status.

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ERCP sometimes requires deep sedation and rarely general anesthesia with airway protection. An objective of birth defect registers is the collection of high quality data, often from a number of sources, for use in epidemiological research. Thirty milligrams of plasminogen, with a specific activity of 100 caseinolytic units (Committee on Thrombolytic Agents) per milligram of nitrogen, were obtained from 340 milliliters of plasma. Do texture-sensitive mechanisms operate separately on, or pool, luminance and colour contrast information?. Safety of glycoprotein IIb/IIIa inhibitors in patients under therapeutic hypothermia admitted for an acute coronary syndrome. Lesioned rats were not impaired in running for a food reward, but their running latencies on day 2 of extinction were lower than those of controls, an indication of perseveration. We assessed attitudes to risk-stratified ovarian cancer (OC) screening based on prior genetic risk assessment using a survey design. Results have implications for family-wide intervention strategies to help lower the risk for early onset obesity in children.

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This macroarray analysis has revealed that two hexose (VvHT1, VvHT3), one polyol (VvPMT5) and one sucrose (VvSUC27) transporter genes, are highly expressed in most vegetative organs. Instead, within wide parts of the target volume, beams with broader energy spectra can be used to simultaneously cover multiple axially adjacent spots of a conventional dose delivery grid as applied in intensity modulated particle therapy. Precipitating Pseudomonas aeruginosa antibodies and antimicrobial therapy in cystic fibrosis patients. This paper presents a new application of the Particle Swarm Optimization (PSO) algorithm to optimize Mel Frequency Cepstrum Coefficients (MFCC) parameters, in order to extract an optimal feature set for diagnosis of hypothyroidism in infants using Multi-Layer Perceptrons (MLP) neural network. We sought to determine the incidence of arteriovenous fistulas (AVF), identify risk factors for AVF, and follow up the clinical outcome of femoral AVF. Our proposed linear-median method has the power to estimate common changes that appear at isolated single probe positions or very short regions. Local adaptation limits lifetime reproductive success of dispersers in a wild salmon metapopulation. However, there were no differences in recurrence-free and cancer-specific survivals among the 56 patients with lower ureteral cancer.

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The PQ-B and the Oviedo Schizotypy Assessment Questionnaire (ESQUIZO-Q) were used. We used data from the US National Household Travel Survey for the years 1995-1996, 2001-2002, and 2008-2009 to estimate the adjusted ratio for the number of trips and trip kilometers made by persons exposed to a GDL law, compared with those not exposed. The recommendations from the 2009 SiHIS working conference in Hiroshima--Issues on trustworthiness of health information and patient safety. As the range of gold nanoparticle types and their applications continues to increase, human safety concerns are gaining attention, which makes it necessary to better understand the potential toxicity hazards of these novel materials. Real-time PCR performed on sera of 27 culture-positive patients showed a significantly higher median DNA load in nonsurvivors than in survivors. Multilineage differentiation of cloned HRA-19 cells in serum-free medium: a model of human colorectal epithelial differentiation. Removing chocolate milk from school cafeterias may reduce calorie and sugar consumption, but it may also lead students to take less milk overall, drink less (waste more) of the white milk they do take, and no longer purchase school lunch. We show that the CC1 antibody binds Quaking 7, an RNA-binding protein that is highly up-regulated in myelinating oligodendrocytes in the central nervous system. Rate and recovery of function were evaluated over a 6-month period in 21 laryngeal cancer patients, 7 in each of 3 treatment groups: total laryngectomy (group 1), hemilaryngectomy (group 2), and radiotherapy only (group 3).

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Immunological consequences of interleukin 12 administration after autologous stem cell transplantation. The serum level of DUPAN-2 returned to normal after the surgery, and has been within normal limits for about 3 years without any additional therapy. The new born unit at Kenyatta National Hospital (KNH) cannot accommodate all neonates so a number of these are admitted to the general paediatric wards. No history of anticipation is present and there is no linkage to the gene locus for DM or to the loci for the muscle sodium or chloride channels. This subsequently led to the development of collaborative infant-specific studies. We used agent-based modeling (ABM) to dynamically represent hypotheses of essential steps involved in circulating tumor cell adhesion and interaction with other circulating cells, examine their functional constraints, and predict effects of inhibiting specific mechanisms. Summary risk estimates for studies controlling for smoking intensity (five of nine studies) or health awareness (two of nine studies) or studies with more than 600 CHD events (three of nine studies) suggest that CP is either not at all or weakly associated with CHD. Influence of probiotic supplemented infant formula on composition of plasma lipids in atopic infants. Treatment with DIZE was not able to reverse hyperglycaemia nor body weight loss.

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Fetal scalp injury like cephalhaematoma was not uncommon but serious scalp injury was infrequent. We computed net change in GHb, stratified by follow-up interval, tested for trial heterogeneity, and calculated pooled effects sizes using random effects models. Whole-plant transpiration and transpiration per unit leaf and root area were affected by treatment, seedlot and phenology. This study has added to the growing evidence on nurse enjoyment and its effects on job satisfaction. Solution of the antiferromagnetic Ising model on a tetrahedron recursive lattice. The equipotency of this soft analog coupled with increased metabolic lability proves the rationality of the soft drug approach for the design of safer therapeutic agents with higher therapeutic indices. Similarly, human data now have emerged showing that arsenic exposure during the in utero period and/or in early life is associated with cancer in adulthood. Trust in the CHWs, level of community awareness and distance to the CHWs are positively associated with the utilisation of ICCM services. It remains a definite palliative option for refractory primary pulmonary hypertension.

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Large-scale, longitudinal Swedish administrative register data are used to study the risk of overnight hospitalization for IHD amongst 67,763 men over the period 1990 to 2001. Blood samples from allogeneic hematopoietic cell transplantation (allo-HCT) patients obtained before, during and after irradiation indicated that exposure led to prolonged clot formation times, increased levels of thrombin-antithrombin III (TAT) complex and increased circulating nucleosome/histone (cNH) levels, which suggest potential coagulopathies in the allo-HCT patients. Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery - a double-blind study. Subjective Global Assessment, handgrip strength, and fat mass were good predictors for the decline in functional status during hospital stay. 220 siblings of patients operated for either abdominal aortic aneurysm or aortoiliac occlusive disease. In contrast, messenger RNA expression of transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10) was increased in cells growing in the presence of L4 products. If surgery is an option, CT-scan or MRI without any contrast media are useful because ultrasound cannot correctly predict the eventual fatty degeneration of the muscles that contra-indicates the surgical treatment. Regardless of the relatively high Spearman correlations between original VAS and VRS, the low ordinal association and low probability of agreement between discrete VAS and VRS suggest that they are not interchangeable.

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Looking through the retrospectoscope: reducing bias in emergency medicine chart review studies. Antithrombic activity after operation, in benicar dose máxima thrombotic diseases, in liver diseases and other diseases. Molecular diagnosis and species identification of Ehrlichia and Anaplasma infections in dogs from Panama, Central America. Laboratory panel estimation of consumer assessments of taste and flavor. Information on the demographics, sexual experience, and obstetrical history of women who attended the Cervical Screening Clinic were collected and tabulated with their Pap smear results to establish the risk factors associated with cervical abnormalities among Hong Kong Chinese women.

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Our analysis has shown that diet quality of pregnant women was poor and intake of micronutrient-rich foods was low despite having knowledge about the importance of these foods, underscoring the need for promoting the diet quality in developing countries through behavior change communication programs. Although MVPA increased from 2002 to 2010 in German adolescents, the time spent in MVPA was still low. Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy. Diagnostic value of hematoma in penetrating arterial wounds of the extremities. The mechanical basis responsible for the development of secondary osteoarthritis in adults and slipped capital femoral epiphysis in adolescents is discussed, with the role of the oblique weight-bearing surface in generating abnormal shearing forces in these two conditions emphasized.

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Effect of vasoactive agents on prostanoid synthesis in isolated rat glomeruli. Evaluation of a textile-based near infrared spectroscopy system in calf muscle oxygenation measurements. Genetic susceptibility to head and neck squamous cell carcinoma. Adoption of a number of behavioral changes may help to overcome barriers to earlier initiation of treatment with bone-targeted agents in these patients. Initial clinical evaluation of cardiac systolic murmurs in the ED by noncardiologists. NGF-TrkA pathway can promote IHCC progression, indicating that NGF-TrkA may become a potential drug target. Information regarding resolution of the 6NP, subsequent vascular events and recurrent ocular motor nerve palsy was obtained from chart review of follow-up clinic visits, mailed questionnaires and telephone interviews.

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Seven putative atopy loci were identified using a genome-wide association study approach but showed limited replication across several white populations. European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of Anaesthesiology Guideline: Non-anesthesiologist administration of propofol for GI endoscopy. This article summarizes the epidemiologic data on the risks and benefits of various infant feeding practices singulair dose pediatric for HIV-infected women living in different contexts. Familial spinocerebellar degeneration as an expression of adrenoleukodystrophy. IL-17 induced phosphorylation of p38 mitogen-activated protein (MAP) kinase. This review attempts to deal with the above matters pragmatically.

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This clp ATPase gene is at least controlled at the posttranscriptional level. Certainly, a new era in TMJ reconstruction has begun, resulting in increased benefits to the patients whom we all serve. The methodologies for measuring effectiveness are discussed, and a critical review of the issues reveals that it is impractical to measure effectiveness directly. Adequate operation interspace is the premise of laparoscopy, and carbon dioxide (CO2) was an ideal gas for forming lacuna. Iron overload and hepatitis C virus (HCV) infection together can lead to chronic liver damage in thalassemia major (TM) patients. Are retailers compliant with zoning regulations that ban tobacco sales near schools in Changsha, China?. Responses to all selection criteria were accompanied with a correlated response in mature weight due to the high genetic correlations between mature weight and the 2 rate parameters.

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This is a retrospective study of 75 early breast cancer patients who received the standard of care and subsequently developed BM. In the PLC group, primary lung tumor TLG was a significant predictor of PFS, while whole-body TLG was found to be a significant predictor in non-PLC patients. We processed the MR images automatically by correcting for inter-individual differences in brain size and shape, and by segmenting the MR images into the gray matter and white matter. The results of this study indicate that the protection of PAI-2 from apoptosis induced by TNF-alpha is dependent upon the protein-protein interaction mediated by the CD-interhelical domain of PAI-2. Summary of the proceedings from the 10th annual meeting of molecularly targeted therapy in non-small cell lung cancer. In contrast, TcTIM monomer binding interface and hTIM dimer interface do not present a specific binding site for the inhibitors.

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